Hot-melt extrusion (HME) tsari ne da aka kafa wanda aka yi amfani dashi tun farkon shekarun 1930, galibi a cikin masana'antar robobi…
Akwai nau'i biyu na extruders: guda da twin dunƙule extruders.Ana amfani da masu fitar da dunƙule guda ɗaya da farko don narkewa da isar da polymers don fitar da su cikin siffofi masu ci gaba, yayin da ake amfani da tagwayen dunƙule extruders don narke-haɗin polymers tare da ƙarin kayan (alamu, filler, ƙarfafawa, da APIs), da kuma sadaukarwa.A cikin samar da magunguna, wanda ke buƙatar Homo-erious da kuma daidaitarwa hade da yawa don samar da daidaito mai ƙarfi wanda ke haifar da cunkoso mai hade da API barbashi, ko ingantaccen maganin API a cikin polymer.Wannan na iya haɓaka ƙimar narkarwar da iyawar bioavail na ƙirar API ɗin da ba ta da ƙarfi-ruwa.API ɗin da aka rarrabawa daidai gwargwado kuma buƙatu ne don samar da na'urorin da ke kawar da ƙwayoyi tare da sake haifar da intra- da tsaka-tsaki na ki-netics-magani.
Ana samun narkewa ta hanyar dumama ganga a cikin ganga, da kuma masu fitar da tagwayen dunƙule, yayin da kayan ke jujjuya su tsakanin sukulan da ke jujjuya da kuma tsakanin skru da bangon ganga yayin da ake isar da su.Hakanan ana dumama ganga tare da dumama dumama akan ganga, ko sanyaya da ruwa.Yanayin yanayin sashin ganga yawanci ana inganta su ta yadda dankon narkewar ya yi ƙasa da ƙasa don ba da damar ɗaukar ganga da cakuɗe da kyau, yayin da ake kiyaye yanayin ƙasa kaɗan don guje wa lalatawar kayan.
Sukurori na tagwayen dunƙule extruder yawanci don samar da nau'ikan yanayi daban-daban na haɗawa da isarwa a yankuna daban-daban a cikin ganga.A yayin haɓaka samfura, sukurori na yau da kullun tare da abubuwa masu yawa waɗanda aka dace akan madaidaicin ramin gama gari, suna ba da damar daidaitawa da haɓaka ƙirar dunƙule don kowane samfur.Za a iya tsara sassan dunƙule don yin raguwar girman barbashi, haɗawa da ayyukan isarwa.An zaɓi tsayin dunƙule dangane da diamita na ganga (rabin L/D) don haɓaka matakin haɗawa da adadin yankuna da ake buƙata don cimma halayen halayen samfur na ƙarshe.Misali na cikakken madaidaicin dunƙulewa.Za a iya gina kusoshi na samarwa guda ɗaya zuwa ƙira ɗaya kamar sukulan haɓakawa, amma sun fi sauƙi don tsaftacewa don bin cGMP.
Lokacin aikawa: Juni-03-2017