Juyawa na sukurori, Akwai iyalai biyu na tagwayen dunƙule extruders, zaɓi na kayan abu yana da mahimmanci a haɓaka samfura mai nasara…
Juyawa na sukurori yana haifar da rarrabuwa da tarwatsa hadawa.Haɗin rarrabuwa yana haɓaka rarrabuwa da sake haɗa kayan yayin da rage ƙarfin shigar da kuzari ta hanyar haɗawa tare da ƙarancin haɓakawa da tasirin-tsare-tsare.Wannan uniformly blends kayan amma ba ya muhimmanci rage tarwatsa abu barbashi size da kuma samar da kadan thermal da karfi ƙasƙanci na m kayan.
Haɗin tarwatsewa yana shafi filayen tsawaitawa da tsarin tsara don karya tarwatsa kayan zuwa ƙarami, da kyau ta amfani da kuzari a sama ko dan kadan sama da matakin da ake buƙata don karya su.
Amfani da daban-daban hadawa abubuwa damar tagwaye dunƙule extruder yi duka barbashi size ragewa da hadawa sabõda haka, APIs za a iya shigar a cikin polymer a tarwatsa tsari ko, idan API solubility a cikin polymer ne high isa, a narkar da tsari.Tun da extrudate yayi sanyi da sauri akan fita daga extruder, duk wani API da aka narkar da shi a cikin polymer a yanayin zafi mai zafi na iya kasa sakewa akan sanyaya, yana haifar da ingantaccen mafita.A irin waɗannan lokuta, dole ne a bi tsarin kwanciyar hankali na samfur a hankali kamar yadda recrystallization na API na tsawon lokaci-ma'auni zai yiwu, musamman a yanayin yanayin ma'auni mai girma da manyan lodin API, kuma yana iya yin tasiri ga rayuwar shiryayye na samfurin ƙarshe.
Akwai iyalai biyu na twin dunƙule extruders: high-gudun makamashi shigar (HSEI) twin-screw extruders, wanda aka farko amfani da compounding, reactive aiki da / ko devolatilization, da low-gudun marigayi Fusion (LSLF) twin-screw extruders, tsara don haɗuwa a ƙananan shear da famfo a matsi na uniform.Sukullun na iya kasancewa suna jujjuyawa (shafa kai), ko jujjuyawar lissafi (rabin kalanda), tare da mafi yawan fitattun abubuwan da ake amfani da su don haɗawa suna juyawa.
Ana amfani da nau'ikan mutuwar fita daban-daban don tsara extrudate zuwa bayanin martaba da ake so.Waɗannan mutuwar sun haɗa da mutuwar takarda da fim ɗin da aka yi amfani da su a aikace-aikacen fim ɗin transdermal, madaidaicin mutun da aka yi amfani da shi don bututun likitanci da wasu na'urorin da ke kawar da muggan ƙwayoyi, mutuƙar mutuƙar da aka yi amfani da ita wajen gyare-gyaren busa, da mutuwar haɗin gwiwa da aka yi amfani da su a ƙirar na'urar tafki.Har ila yau, ana amfani da wasu abubuwan taimako na ƙasa daban-daban a cikin aikin gamawa, gami da wanka na ruwa da wukake na iska don sanyaya, bel na jigilar kaya don motsi samfurin da aka fitar daga mutu zuwa ƙarshen layin, masu yanke-yanke don yanke extrudate cikin bututu ko sanduna, da spoolers don tarin extrudate.Ana amfani da pelletizers don yanke extrudate zuwa ƙananan guntu don cika capsule kai tsaye da kuma yanayin wasu na'urori don gyare-gyaren allura don samar da samfurin ƙarshe.
Kamar kowane nau'i na sashi, zaɓin kayan abu yana da mahimmanci wajen haɓaka samfur mai nasara.Don yawancin aikace-aikacen, polymer ya kamata ya zama thermoplastic, barga a yanayin yanayin da ake amfani da shi a cikin tsari, kuma ya dace da kemikal tare da API yayin extrusion.Don ƙwararrun siffofin na baka, yawanci ana zaɓaɓɓen polymers wanda aka riga aka yi amfani da shi a cikin samfuran polymers kamar poly (etylpyrololide).Tare da ƙarin sha'awar amfani da HME don samfuran magunguna, manyan masu samar da polymer suma sun fara ba da polymers musamman waɗanda aka ƙera don aikace-aikacen magunguna.Don na'urori masu kawar da ƙwayoyi, polymers gabaɗaya ba su da ruwa, kuma yawancin samfuran da ke ƙarƙashin haɓaka suna amfani da ko dai ethylene vinyl acetate copolymers (EVAs) ko polyurethane.
HME yana ba da damar API don haɗawa da polymer a ƙarƙashin ƙaramin ƙarfi da matsananciyar zafi kuma saboda haka tare da samar da ƙarancin abubuwan lalata API masu alaƙa da tsari.Yawancin lokaci ana haɗa Antioxidants a cikin tsarin, kuma ɗan gajeren lokacin zama a cikin ganga (yawanci akan tsari na mintuna) shima yana taimakawa wajen rage lalatawar thermal musamman idan aka kwatanta da haɗuwa da tsari da sauran hanyoyin haɓakawa.
Dabaru ɗaya don sarrafa ilimin kinetics na miyagun ƙwayoyi daga na'urori irin su zoben cikin farji sun haɗa da haɓaka dabarun extrusion mai sauƙi.Fitarwa na lokaci guda na madaidaicin madaidaicin ƙwayar cuta tare da kumfa mai sarrafa ƙwayar cuta ta polymer wanda ke ɗaukar ainihin a cikin tsari guda ɗaya na haɗin gwiwa yana samar da madaidaicin ƙwanƙwasa mai Layer biyu.Ana ciyar da shugaban extrusion na musamman da na'urori biyu na perpendicular - wanda ke ba da ainihin abun da ke ciki, ɗayan yana ba da kayan kwasfa.An yanke madaidaicin sheath kuma an haɗa iyakar don yin na'urar ta ƙarshe.
HME tana ba da masu haɓaka samfura na na'urorin likitanci, narkar da nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan magunguna tare da zaɓin tsari wanda ke haɓaka haɗawar API tare da polymer, yayin da rage lalata API, har ma yana buɗe kofa ga samfuran waɗanda ba za a iya shirya su ta wasu hanyoyi ba.
Lokacin aikawa: Agusta-01-2017